Wednesday, July 6, 2016

White House proposes measures to speed genomic test development

WASHINGTON: The White House announced on Wednesday measures aimed at advancing President Barack Obama's precision medicine initiative, including plans to speed the development of tests used to identify genetic mutations and guide medical treatment.

The US Food and Drug Administration said it planned to issue a proposal on Wednesday to create performance standards to guide development of next generation sequencing (NGS) tests. These tests scan a person's DNA and identify genetic differences that could be responsible for a patient's symptoms.

The standards would be designed to assess how accurately a test identifies a genetic variant. The developer would certify that it had met those standards. Currently the FDA itself determines the test's accuracy.

"We believe that the use of standards is the best way to allow regulation to keep pace with the evolution of NGS technology," Dr. Robert Califf told reporters on a conference call.

A second FDA proposal would allow test developers to use data from publicly accessible genetic databases, not just their own data, to demonstrate that the test accurately predicts disease. Califf said the approach could potentially get rid of the need for the FDA to review the tests before they reach the market.

"Taken together, these guidances will foster innovation, assure the quality and reliability of NGS-based tests and promote their adoption into clinical practice," he said.

The FDA's action is part of a broader government initiative to promote the development of individually tailored medicines. Obama introduced the initiative in his State of the Union address last year, saying he wanted the United States to lead a new era of medicine, "one that delivers the right treatment at the right time."

As part of the project, the National Institutes of Health will invest $55 million to build the infrastructure needed to collect genetic data from more than 1 million volunteers, its director, Dr. Francis Collins, said on the conference call.

Collins said it will take three to four years to assemble the desired amount of genetic material, which will then be available to researchers to help develop drugs for cancer and other disease. Anyone, he said, can participate.

"This is about all of us," he said. "Participants will be true partners, not subjects, not patients." Data sharing, he added, will be "swift."

Policeman dead after blast at Bangladesh Eid prayers

Dhaka: At least one policeman was killed and five others wounded Thursday after a small bomb exploded near a mass Eid prayer congregation in Bangladesh, police said.

Police and local media said the explosion occurred at a school outside the prayer ground in the northern Kishoreganj district where at least 200,000 people were gathered. There were also exchanges of gunfire at the scene.

"One police constable is dead and at least five others were injured," Mahbub, a police officer in the Kishoreganj control room, told AFP.

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Modi calls PM Nawaz on Eid, wishes him well post-surgery

ISLAMABAD: Indian Prime Minister Narendra Modi telephoned his Pakistani counterpart Nawaz Sharif on Wednesday, the holiday of Eid, to wish him a speedy recovery from surgery, a sign the two men remain in touch, despite fraught diplomatic relations.

Sharif, 66, had successful open heart surgery in a London hospital in May, his second cardiac procedure in five years.

"Indian Prime Minister Modi called Prime Minister Sharif on the occasion of Eid," Sharif´s office said in a statement.

"He also wished him well for his health post-surgery."

Wednesday is a national holiday in Pakistan, marking the end of the holy month of Ramazan, when Muslims fast from dawn till dusk.

Before the surgery in May, Sharif had also telephoned Modi to thank him for his wishes for a quick recovery.

Sharif made a bid to improve ties with old rival India a key plank of his 2013 election campaign, though progress has been slow and relations remain frayed over militant attacks and long-standing distrust.

Modi calls PM Nawaz on Eid, wishes him well post-surgery

ISLAMABAD: Indian Prime Minister Narendra Modi telephoned his Pakistani counterpart Nawaz Sharif on Wednesday, the holiday of Eid, to wish him a speedy recovery from surgery, a sign the two men remain in touch, despite fraught diplomatic relations.

Sharif, 66, had successful open heart surgery in a London hospital in May, his second cardiac procedure in five years.

"Indian Prime Minister Modi called Prime Minister Sharif on the occasion of Eid," Sharif´s office said in a statement.

"He also wished him well for his health post-surgery."

Wednesday is a national holiday in Pakistan, marking the end of the holy month of Ramazan, when Muslims fast from dawn till dusk.

Before the surgery in May, Sharif had also telephoned Modi to thank him for his wishes for a quick recovery.

Sharif made a bid to improve ties with old rival India a key plank of his 2013 election campaign, though progress has been slow and relations remain frayed over militant attacks and long-standing distrust.

US to keep 8,400 troops in Afghanistan into 2017: Obama

WASHINGTON: President Barack Obama announced Wednesday that 8,400 US troops will remain in Afghanistan into 2017 in light of the still "precarious" security situation in the war-ravaged country.

"Instead of going down to 5,500 troops by the end of this year, the United States will maintain approximately 8,400 troops in Afghanistan into next year through the end of my administration," Obama told a news conference.

"The decision I´m making today ensures my successor has a solid foundation for continued progress in Afghanistan, as well as the flexibility to address the threat of terrorism as it evolves," he said.

The current number of US troops in Afghanistan is 9,800.

Obama´s announcement is further acknowledgement that Afghan security forces, who took charge of the country´s security in 2015, are still not ready to go it alone.

They have suffered a devastating string of setbacks at the hands of the Taliban, including the temporary loss of the city of Kunduz, and more than 5,000 Afghan troops were killed last year alone.

Other organizations, including the Daesh (Islamic State group), have also stepped up activity.

"The security situation in Afghanistan remains precarious," Obama said.

"Even as they improve, Afghan security forces are still not as strong as they need to be. With our help, they´re still working to improve critical capabilities, such as intelligence, logistics, aviation and command and control."

Obama´s decision comes after General John Nicholson, the new commander of the US-led NATO mission in Afghanistan, this year conducted a review of the security situation.

Republican Senator John McCain, a longtime critic of Obama´s military policies, praised the move, but said the president should have kept the entire 9,800 US troops in country.

Still, he said, "the decision to retain 8,400 US troops in Afghanistan into next year is certainly preferable to cutting those forces by nearly half."

PM to return on Saturday after doctors? green signal

ISLAMABAD: Prime Minister Nawaz Sharif will return to Pakistan on Saturday after the doctors in London allowed him to travel after his heart surgery, sources said Wednesday.

According to the sources, the Premier will arrive in Lahore via special plane after he insisted to his doctors’ in London to grant him permission return to the motherland.

Nawaz Sharif’s brother and Chief Minister Punjab Shahbaz Sharif, Hamza Shahbaz and others will accompany the PM, the sources further said.

PM Nawaz underwent open heart surgery in a London hospital on May 31, his second cardiac procedure in five years.

 

PM to return on Saturday after doctors? green signal

ISLAMABAD: Prime Minister Nawaz Sharif will return to Pakistan on Saturday after the doctors in London allowed him to travel after his heart surgery, sources said Wednesday.

According to the sources, the Premier will arrive in Lahore via special plane after he insisted to his doctors? in London to grant him permission return to the motherland.

Nawaz Sharif?s brother and Chief Minister Punjab Shahbaz Sharif, Hamza Shahbaz and others will accompany the PM, the sources further said.

PM Nawaz underwent open heart surgery in a London hospital on May 31, his second cardiac procedure in five years.

 

UK´s Iraq war inquiry delivers damning verdict on Blair

LONDON: Former British Prime Minister Tony Blair took his country into a badly planned, woefully executed and legally questionable war in Iraq in 2003, according to the findings of a long-delayed inquiry published Wednesday.

The Chilcot report said Britain joined the US-led invasion before all other options had been exhausted and on the basis of false intelligence that Iraqi leader Saddam Hussein had weapons of mass destruction.

Blair faced particular criticism for pledging to support US president George W. Bush the year before the invasion, writing: "I will be with you, whatever".

Blair failed to ensure "there was a flexible, realistic and fully resourced plan", said the report, which found preparations for occupation after the initial invasion were "woefully inadequate".

More than 150,000 Iraqis had died by the time most British troops withdrew in 2009, while 179 British soldiers also lost their lives.

The country remains plagued by sectarian violence, as shown notably by Sunday´s Baghdad suicide bombing claimed by Daesh (Islamic State) which killed at least 250 people.

In a statement, Blair said he had acted "in good faith and in what I believed to be the best interests of the country".

He said he took "full responsibility for any mistakes, without exception or excuse", but added: "I believe that it was better to remove Saddam Hussein."

The inquiry drew a different conclusion.

It found that "military action in Iraq might have been necessary at some point. But in March 2003 there was no imminent threat from Saddam Hussein."

Britain´s scarring experience in Iraq has made it deeply wary of committing ground troops to international military interventions in countries like Syria and Libya.

Unveiling the 2.6 million-word report, which took seven years to complete, inquiry chairman John Chilcot said it was "an account of an intervention which went badly wrong, with consequences to this day".

More than 100 anti-war protesters gathered outside the conference centre where the report was published, with many shouting: "Blair lied, thousands died" and "war criminal Tony Blair".

Relatives of some of the soldiers killed said the report could form the basis of legal action against Blair and other officials.

"The inquiry has confirmed all our fears that these young men and women were deployed on the back of a falsehood," said Roger Bacon, whose son Matthew, 34, died in 2005.

"We reserve our right to call specific parties to answer for their actions in the courts, if such process is found to be viable."

Rose Gentle, who lost her 19-year-old son Gordon, said the findings were "gut-wrenching"  and dismissed Blair´s response.

"I hold him responsible for the murder of my son," she told reporters.

Peaceful options not exhausted

Although the legality of the invasion was not in his remit, retired civil servant Chilcot said the process of deciding the legal basis for war was "far from satisfactory".

"We have concluded that the UK chose to join the invasion of Iraq before the peaceful options for disarmament had been exhausted. Military action at that time was not a last resort," he said.

The report laid the blame for mistaken fears of Saddam´s WMD firmly on the intelligence community, but said the government had "overstated the firmness of the evidence" about Iraq´s capabilities and intentions.

It confirmed long-held suspicions that Blair put Britain on a path to war as early as July 2002.

Blair was also criticised for failing to challenge Bush on the lack of planning for the aftermath of the invasion.

It dismissed Blair´s assertion that it was not possible to predict the strength of local opposition, the rise of Al-Qaeda and the involvement of Iran, which all fuelled the violence, saying these were "explicitly identified before the invasion".

´Lessons learned´

The inquiry was called under pressure from relatives, concerned about the justification for the war as well as poor military equipment, over which the Ministry of Defence was strongly criticised in the Chilcot report.

The families are not the only ones considering legal action against Blair -- a cross-party group of MPs is also looking into the possibility, including of taking a case to the International Criminal Court.

The war, which at one point saw 46,000 British troops deployed, mostly in southern Iraq around the strategic oil hub of Basra, still looms large over British politics.

In a statement to the House of Commons, Prime Minister David Cameron said that all the MPs who voted for the war must "take our fair share of the responsibility.

"We cannot turn the clock back but can ensure that lessons are learned and acted on," he said.

Cameron said new procedures to ensure "proper separation" between intelligence and the process for assessing has already been put in place.

"Taking the country to war should always be a last resort," he said, adding however that "we should not conclude that intervention is always wrong".

Opposition leader Jeremy Corbyn, the current head of Blair´s Labour party, said the war was "an act of military aggression launched on a false pretext" that "fuelled and spread terrorism across the region".

Pakistan will not allow anyone to use its soil against Afghanistan: COAS

RAWALPINDI: Chief of Army Staff General Raheel Sharif on Wednesday said that Pakistan will not allow anyone to use its soil against Afghanistan and directed all commanders and Law Enforcement Agencies to take concrete measures against violators, an Inter Services Public Relations (ISPR) statement said.

According to the statement, COAS said, “peace and stability along Pak-Afghan border remains our priority; towards which we will commit all our efforts.”

 He said border management and dignified repatriation of Afghan refugees are important enablers for lasting peace.

“Our efforts for peace in Afghanistan have been acknowledged. While we are committed to facilitate the reconciliation process with sincerity, commitment, and resolve, we expect non-use of Afghanistan territory against Pakistan.”

COAS said that the nation and Pakistan Army have paid a huge price for eliminating terrorist and restoring peace in the country.

“We will not let these sacrifices go waste. With FATA cleared and terrorists being chased across the country, we are determined not to allow them to return and reverse our gains.” ISPR quoted COAS as saying.

COAS stated that the operations against terrorists of all hue and colour will continue.

“As consolidation goes on and operational dividends optimized for Pak-Afghan Border region, Pakistan will not allow anyone to use its soil against Afghanistan and directed all commanders, int agencies, and LEAs to take concrete measures against violators.”, said the statement.

COAS spent his Eid day visiting troops in the forward area in North and South Waziristan Agency on Wednesday, ISPR said.

The statement said that COAS offered his Eid prayers at Shawal and interacted with troops. Later, he visited Datta Khel where he met with troops.

ISPR statement further said that General Raheel was briefed by Corps Commander and Formation Commander in detail, about ongoing sanitization and stabilization operation as part of Zarb-e- Azb and post operation security environment.

Earlier on arrival on the front lines, COAS was received by Lt General Hidayat Ur Rehman, Corps Commander Peshawar.

Pakistan will not allow anyone to use its soil against Afghanistan: COAS

RAWALPINDI: Chief of Army Staff General Raheel Sharif on Wednesday said that Pakistan will not allow anyone to use its soil against Afghanistan and directed all commanders and Law Enforcement Agencies to take concrete measures against violators, an Inter Services Public Relations (ISPR) statement said.

According to the statement, COAS said, ?peace and stability along Pak-Afghan border remains our priority; towards which we will commit all our efforts.?

 He said border management and dignified repatriation of Afghan refugees are important enablers for lasting peace.

?Our efforts for peace in Afghanistan have been acknowledged. While we are committed to facilitate the reconciliation process with sincerity, commitment, and resolve, we expect non-use of Afghanistan territory against Pakistan.?

COAS said that the nation and Pakistan Army have paid a huge price for eliminating terrorist and restoring peace in the country.

?We will not let these sacrifices go waste. With FATA cleared and terrorists being chased across the country, we are determined not to allow them to return and reverse our gains.? ISPR quoted COAS as saying.

COAS stated that the operations against terrorists of all hue and colour will continue.

?As consolidation goes on and operational dividends optimized for Pak-Afghan Border region, Pakistan will not allow anyone to use its soil against Afghanistan and directed all commanders, int agencies, and LEAs to take concrete measures against violators.?, said the statement.

COAS spent his Eid day visiting troops in the forward area in North and South Waziristan Agency on Wednesday, ISPR said.

The statement said that COAS offered his Eid prayers at Shawal and interacted with troops. Later, he visited Datta Khel where he met with troops.

ISPR statement further said that General Raheel was briefed by Corps Commander and Formation Commander in detail, about ongoing sanitization and stabilization operation as part of Zarb-e- Azb and post operation security environment.

Earlier on arrival on the front lines, COAS was received by Lt General Hidayat Ur Rehman, Corps Commander Peshawar.

Barcelona´s Messi sentenced to 21 months for tax fraud

MADRID: Barcelona soccer star Lionel Messi has been sentenced to 21 months in prison after a court in Barcelona found him guilty of three counts of tax fraud, a statement from the court said on Wednesday.

The court also sentenced the Argentine soccer player´s father, Jorge, to 21 months in prison for the same three crimes.

The sentence can be appealed through the Spanish supreme court, the statement said.

However, under Spanish law a prison sentence under two years can be served under probation, meaning Messi and his father are unlikely to go to jail.

The court ordered Messi to pay a fine of around 2 million euros ($2.21 million) and his father to pay 1.5 million euros for the crimes.

Barcelona´s Messi sentenced to 21 months for tax fraud

MADRID: Barcelona soccer star Lionel Messi has been sentenced to 21 months in prison after a court in Barcelona found him guilty of three counts of tax fraud, a statement from the court said on Wednesday.

The court also sentenced the Argentine soccer player´s father, Jorge, to 21 months in prison for the same three crimes.

The sentence can be appealed through the Spanish supreme court, the statement said.

However, under Spanish law a prison sentence under two years can be served under probation, meaning Messi and his father are unlikely to go to jail.

The court ordered Messi to pay a fine of around 2 million euros ($2.21 million) and his father to pay 1.5 million euros for the crimes.

Pistorius jailed for six years for murdering girlfriend

PRETORIA: South African Paralympian Oscar Pistorius was sentenced on Wednesday to six years in jail for murdering his girlfriend Reeva Steenkamp at his home three years ago.

High Court judge Thokozile Masipa listed several mitigating factors for sentencing Pistorius to less than half the minimum 15-year term for murder, including the athlete´s claim he believed he was shooting an intruder.

"He cannot be at peace. I´m of the view that a long term of imprisonment will not serve justice," Masipa said.

"He´s a first offender. Considering the facts of this matter he´s not likely to re-offend.

"The sentence that I impose on the accused... is six years imprisonment."

Pistorius´ lawyer Andrew Fawcett said he would not appeal the term.

Parole conditions vary in South Africa, but the double-amputee Olympic sprinter may be able to apply for parole after serving just three years in jail.

Pistorius, 29, hugged his family before being taken out of the court in Pretoria to begin serving his sentence.

He was freed from prison last October after serving one year of a five-year term for culpable homicide -- the equivalent of manslaughter.

But an appeals court upgraded his conviction to murder in December.

Steenkamp´s parents looked on quietly as the judge passed sentence.

"We let the law run its course, nothing will bring Reeva back," the family´s lawyer Petrus de Bruyn told AFP afterwards.

Pistorius shot Steenkamp, a model and law graduate, in the early hours of Valentine´s Day in 2013, saying he mistook her for a burglar when he fired four times through the door of his bedroom toilet.

His long legal battle may not yet be at an end, with the state yet to confirm whether it will appeal a sentence seen by experts as lenient.

"We are very disappointed... from five years that we fought against, and now it is six, what is that?" Jacqui Mofokeng, spokeswoman of the ruling ANC party´s women league, told AFP after the sentencing.

"It´s an insult to the women of South Africa."

´Fallen hero´

A challenge by the prosecution to the Supreme Court of Appeal would be another blow to Masipa, who issued the original culpable homicide verdict that was later overturned.

Many legal experts said they had expected a term of between 11 and 14 years.

Pistorius, dressed in black tie, white shirt, and black jacket, stared straight ahead in court during Wednesday´s televised proceedings.

"Thankfully, healing has already started, Mr and Mrs Steenkamp have stated they have forgiven the accused," the judge said in her ruling.

"The life of the accused shall also never be the same. He is a fallen hero who has lost his career and he is ruined financially."

At his sentencing hearing last month Pistorius, sobbing heavily, hobbled on his stumps across the courtroom to demonstrate his physical vulnerability.

His lawyers had argued he should not be returned to jail on account of his anxiety disorder and depression.

Pistorius, who pleaded not guilty at his trial in 2014, has always denied killing Steenkamp in a rage, saying he was trying to protect her.

The Supreme Court of Appeal in December ruled he was guilty of murder, irrespective of who he believed was behind the door, when he opened fire with a high-calibre pistol he kept under his bed.

The year before he killed Steenkamp, Pistorius became the first double-amputee to race at the Olympic level when he appeared at the London 2012 games.

He told a recent television interview that he believed Steenkamp would want him to devote his life to charity rather than return to prison for killing her.

"I don´t want to go back to jail," he said. "If I was afforded the opportunity of redemption, I would like to help the less fortunate."

"I would like to believe that if Reeva could look down upon me that she would want me to live that life."

Sir John Chilcot's Iraq War Inquiry report out today

The Iraq War Inquiry also known as the Chilcot Inquiry report on Britain's role in the Iraq war is due to be released today (Wednesday). The report is being released seven years after the inquiry was first launched and approximately 13-years after British troops were sent to Iraq. 

A large crowd has gathered in Central London where expectations vary of what to expect from the report. 

Parents of a Major deployed with the Intelligence Corps who was killed in an improvised explosive device (IED) explosion in 2005 told British media that there would be ?something terribly wrong with our political process? if the Chilcot Report did not produce grounds for the families of dead soldiers to take legal action over the Iraq war.

The parents accused Tony Blair of betraying their son and misleading Britain into a war that was ?a total and utter catastrophe?, reported the Independent

While Sir John Chilcot made it clear early on that he will not rule on whether the invasion of Iraq was legal with regards to international law, but pledged that he would provide a "full and insightful" account of the decision-making. 

Longest report in history

The approximately 2.6-million-word report is being termed as the longest report in the history. Two put things into perspective, the entire Harry Potter series is about 1-million words long. Some news outlets have estimated that it would take nine days to complete reading the Chilcot report.

Will the Chilcot report have an impact, will it give the grieving parents the right to legal recourse? Here are some of the likely ramifications:

Tony Blair

The former Labour prime minister took Britain into the US-led invasion, making the case to the public and parliamentarians, many of whom were strongly opposed.

The justification was that Iraqi leader Saddam Hussein had weapons of mass destruction (WMD), but these were never found and the intelligence was later severely criticised.

Blair's close relationship with US president George W. Bush led to accusations that he privately pledged British support for the war well before parliament agreed to it.

During the war, the International Criminal Court was petitioned to investigate alleged war crimes by Blair and his ministers relating to Iraqi civilian casualties.

The court has said it would look at the Chilcot report but noted it cannot rule on the legality of the war and could only act if British courts first refused to take up the case.

A group of MPs led by former Scottish first minister Alex Salmond is also investigating possible legal action and whether Blair could be retrospectively impeached.

In a CNN interview last year, Blair said: "I apologise for the fact that the intelligence we received was wrong."

He added: "I also apologise for some of the mistakes in planning and, certainly, our mistake in our understanding of what would happen once you removed the regime.

"But I find it hard to apologise for removing Saddam."

Relatives of soldiers killed

Relatives of the 179 British soldiers killed in Iraq had pressed for the inquiry, amid criticism of the motivation, planning and management of the conflict, and accusations that the troops were not properly equipped.

Lawyers will be scouring the report for any potential basis for legal action against Blair, other officials or the Ministry of Defence, likely based on misconduct in office or neglect of duty.

However, some relatives are reportedly boycotting the launch, already convinced it will be a whitewash.

Military & Intelligence Chiefs

The inquiry is expected to deal extensively with the failures in the military operation, from the planning of the war to the occupation, during which Iraq descended into sectarian violence from which it has yet to emerge.

"There is already general recognition that there were systemic failures in the operation after we entered Basra and the south," said Malcolm Chalmers, deputy director general of the Royal United Services Institute think tank.

He said British forces underestimated the strength of the local opposition and the determination of regional powers -- notably Iran -- to undermine the US and Britain.

Previous reports have criticised the failures in intelligence that led to the conclusion that Iraq had WMD, and how that was used by politicians -- but Chilcot could add to this.

Britain's Chief of Defence Staff Nick Houghton, who was a senior British military commander in the Iraq war, could be singled out for criticism, the Guardian newspaper reported earlier this year.

Opposition Labour leader Jeremy Corbyn, who is facing a rebellion by more than 80 percent of his MPs, is expected to use the Chilcot report to bolster his position.

The veteran socialist was strongly opposed to the war in Iraq and maintains it was illegal, while many of those trying to unseat him had supported it.

But one of his supporters, Paul Flynn, said that "parliament is on trial" over the war.

"It was not just one man; it was hundreds of MPs, three select committees of this House, the military and the press who were in favour of joining a war in pursuit of non-existent weapons of mass destruction," he said.

US-British Relations

The report will reportedly include 29 letters sent by Blair to Bush in the run-up to the invasion, which will only be lightly redacted.

There will also be some form of record of conversations between them, as well as between their successors Gordon Brown and Barack Obama.

Diplomatic wrangling over what could be published was one of the reasons why the Chilcot report took so long.

At least 10 killed in double suicide bombing in Yemen's Aden

ADEN: At least 10 were killed including Yemeni troops while dozens were wounded on Wednesday when two suicide bombers blew up their cars at a military base in the southern city of Aden, security sources said.

About two dozen militants launched an attack on the soldiers inside the base after the explosions. Gun battles at the base, in the Khor Maksar district, were going on and military reinforcements were arriving, the sources said.

The attacks followed bombings in three Saudi cities on Monday, after days of mass killings in attacks in Turkey, Bangladesh and Iraq apparently by the Islamic State group as the Islamic holy month of Ramadan draws to a close.

Islamist militants have gained territory and freedom to operate in Yemen thanks to a war raging for more than a year in which government forces have been pitted against Iran-allied Houthi rebels who control the capital, Sanaa.

Yemeni security officials believe there is an overlap between adherents of al Qaeda and Islamic State, though the two groups are ideological rivals and compete for recruits.

Al Qaeda has used the security vacuum to seize control over swathes of southern and eastern Yemen, while Islamic State has launched several mass-casualty attacks on security forces.

Three coordinated Islamic State bomb attacks on government troops killed 38 people in the southern port city of Mukalla on June 27 as they were preparing to break their dawn-to-dusk fast during Ramadan.

Dhaka attack neighbourhood falls silent ahead of Eid

DHAKA: An eerie silence pervades the restaurants and shopping malls in Dhaka´s diplomatic quarter, usually teeming with well-heeled urbanites, now standing empty since the killing of 20 hostages at a popular cafe.

Five days after the siege at the Holey Artisan Bakery in the Bangladeshi capital, many establishments remain closed, with shaken residents of Gulshan too afraid to venture out.

"Our guest numbers have gone down dramatically so the management took the decision to keep it shut for a while," said Abdul Mazid, a guard at Meraki, a well-known restaurant in the neighbourhood.

The run-up to Eid celebrations that mark the end of the holy month of Ramadan usually see shopping malls overflowing with crowds and millions of dollars changing hands in just a few days.

But this year Gulshan DCC market, usually bustling with Eid shoppers ahead of the biggest festival in the Muslim calendar, stand deserted.

The festivities, which start in earnest on Thursday, are likely to be subdued, with attendees instructed not to bring bags and high security at the National Eidgah Maidan in central Dhaka, where thousands will congregate for prayers in one of the largest such gatherings.

At least five gunmen stormed the bakery on Friday evening, sparking an 11-hour stand-off with police that saw victims murdered with machetes, most of them Italian or Japanese.

Around the corner from the site of the attack, Thai restaurant Soi 71 and neighbouring Korean diner Suraon, which usually remain lively past midnight, were shuttered on Tuesday.

"Ours is a happening business, it´s hard to believe how quiet it has become over the past few days," said Mohammad Farhan, manager of the upmarket Butlers Chocolate Cafe, where waiters were standing around.

Britain was among countries urging its citizens to avoid areas frequented by foreigners, such as international hotels, large supermarkets or clubs, while Japanese firm Uniqlo restricted non-urgent travel for employees.

As Dhaka residents attempt to regroup, fears are mounting that the attack may herald an escalation of violence in Bangladesh.

Islamist militants have been blamed for a wave of murders of foreigners, religious minorities and secular writers over the past three years.

Different targets, different countries: The challenge of stopping Islamic State

Deadly attacks in four countries linked to Islamic State show the limitations of U.S.-led efforts to loosen the group's grip in Syria and Iraq, and the challenge of stopping attacks that are not only globally dispersed but very different in their choice of targets, current and former U.S. officials said.

"Bombing the heck out of (Islamic State's capital) Raqqa is not going to stop this stuff," said Paul Pillar, a veteran CIA analyst now at Georgetown University.

In recent months, Obama administration officials have frequently portrayed the group's deadly strikes worldwide as a direct response to the U.S.-led military coalition's success in ousting it from large tracts of Iraq and Syria.

While that may be true in part, the current and former U.S. officials said, it is overly simplistic and understates how Islamic State's influence has spread beyond the territory it controls.

The ultra-hardline Sunni Muslim group's recruiting and propaganda directed outside its self-proclaimed caliphate long predates its loss of key cities in Iraq such as, most recently, Falluja, U.S. officials said.

"Evidence has been growing for some time that ISIS has been expanding its outreach, recruiting and propaganda, both online and with emissaries, as the military and economic costs of maintaining, much less expanding, its original caliphate have become clear," said a U.S. official who closely watches militant Islamic groups.

In its new guise, some analysts said, Islamic State is coming to more closely resemble al Qaeda, which has primarily focused on large-scale attacks rather than try to hold territory.

Building and maintaining a caliphate has possibly been more expensive and complicated than Islamic State first realized, the U.S. official said.

U.S. officials said they are still analyzing the links between Islamic State and a June 28 attack on Istanbul airport that killed 45 people; an attack on a cafe frequented by foreigners in Dhaka on Friday that killed 20 people; a suicide truck bombing in a mainly Shi'ite Baghdad neighborhood on Saturday that killed at least 175 people; and attacks in Saudi Arabia targeting U.S. diplomats, Shi'ite worshippers and a security office at a mosque in the holy city of Medina.

All took place during the Muslim holy month of Ramadan, which ends this week with the Eid al-Fitr feast.

A U.S. official said the attacks in Turkey, Iraq and Saudi Arabia appear to have direct links to Islamic State. The one in Bangladesh may have been Islamic State-inspired but also have local roots, the official said.

Intercepted Islamic State messages suggest targets to attack, including gathering places for non-Muslims and Shi'ite Muslims in predominantly Sunni areas, and government installations, another U.S. official said.

"There's a fair amount that falls somewhere in between inspiration and outright direction," this official said. "Call it suggestion."

Counter-terrorism experts say there is no silver bullet that will stop strikes on civilians that are so globally dispersed and use methods of attack that range from single suicide bombers to massive truck bombs to hostage-taking.

"The challenge involved is, the action and initiative is coming from a lot of different places," said Georgetown's Pillar.

Closer diplomatic cooperation, intelligence sharing and tracking money flows were crucial, he said.

"We've always made clear that the military campaign is not enough to defeat Daesh (Islamic State) or to remove the threat that it poses," State Department spokesman John Kirby said on Tuesday. "A holistic campaign that addresses the root causes of extremism is the only way to deliver a sustainable defeat.

Seven killed in military helicopter crash in northern Turkey, army says

Seven people were killed and eight injured when a helicopter carrying Turkish military personnel, their wives and children crashed in the Black Sea region of northeast Turkey on Tuesday, the Turkish armed forces said.

The cause of the Sikorsky helicopter's crash, as it returned to the town of Giresun from a visit to military outposts in the area, could not immediately be determined, a statement on the military's website said.

However, the prime minister and one of his deputies said poor weather was responsible, rather than a militant attack. The Turkish armed forces are involved in a conflict with Kurdish militants focused in the country's southeast.

Those on board, who according to media reports included a brigadier general, had been visiting military personnel and their families at gendarmerie outposts to mark the Eid al-Fitr holiday at the end of the Muslim holy month of Ramadan.

"Unfortunately, seven people among our comrades in arms, their wives and children lost their lives and the eight injured people were immediately sent to hospitals in the region," the army said, without specifying who had died.

Rescue teams and ambulances rushed to the site of the crash, but local residents arrived first. Video broadcast by CNN Turk showed locals helping the wounded down a hillside and taking them in their vehicles to nearby hospitals.

The helicopter crashed at around 5:15 pm (1415 GMT) near Tohumluk village in the Alucra district of Giresun province, the military said.

As well as a brigadier general, on board were two colonels and other officers, along with four of their wives and three children, the private news agency Dogan reported.

Earlier, Prime Minister Binali Yildirim said the crash, which occurred in the highlands of Giresun province, appeared to be an accident caused by bad weather.

"It is understood to be an accident resulting purely from poor weather conditions," Yildirim told reporters in televised comments.

Deputy Prime Minister Nurettin Canikli, who traveled to the area of the crash, later echoed Yildirim's words in comments to reporters and ruled out the possibility that an attack could have been responsible.

In May, the army said a military helicopter that had crashed a week earlier may have been brought down by Kurdish militants with a ground-to-air missile.

Muslim countries should play active role in developing ummah: Imran Khan

ISLAMABAD: Pakistan Tehreek-e-Insaf (PTI) chairman wished Pakistanis and Muslims across the world a happy Eid Mubarak and urged leaders to play an active role in developing the Muslim ummah.

Taking to twitter, Khan wished the country Eid Mubarak a little early. 

PTI chief Imran Khan also said that the wealth of the nation was not being spent on the masses but only a select few individuals were withholding it. Khan stated that the message of patience and perseverance that Ramazan had taught should be implemented by everyone. He urged all to rise from self-interests and place the general welfare of the community before everything else. 

Imran also urged the global community to adopt seriousness to tackle poverty, illiteracy, division and exploitation. He stated that it was time to stop those who kill the general welfare for their own benefits. 

The PTI chief is expected to leave for London on the third day of Eid. 

No threats to leave the country, Sabri family rejects rumours

KARACHI: Law enforcement agencies continue to probe leads in hopes of solving murder of Amjad Sabri who was gunned down in broad daylight in the southern metropolis last month. While law enforcers continue to make a breakthrough in solving the murder, rumours that the slain qawal's family was receiving threats to leave the country have been put to rest. 

Sarwat Sabri, brother of the slain qawaal clarified on Tuesday, that the rumours were not true. He told journalists, "one day has been fixed for death and we do not fear it," he added, "We wish we get martyred".

He prayed that his brothers killers be brought to justice. 

Amjad Sabri was an internationally renowned qawaal who was gunned down in Karachi on June 22. His murder shocked his fans in Pakistan and across the world.

 

No threats to leave the country, Sabri family rejects rumours

KARACHI: Law enforcement agencies continue to probe leads in hopes of solving murder of Amjad Sabri who was gunned down in broad daylight in the southern metropolis last month. While law enforcers continue to make a breakthrough in solving the murder, rumours that the slain qawal's family was receiving threats to leave the country have been put to rest. 

Sarwat Sabri, brother of the slain qawaal clarified on Tuesday, that the rumours were not true. He told journalists, "one day has been fixed for death and we do not fear it," he added, "We wish we get martyred".

He prayed that his brothers killers be brought to justice. 

Amjad Sabri was an internationally renowned qawaal who was gunned down in Karachi on June 22. His murder shocked his fans in Pakistan and across the world.

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